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Tesamorelin

Also known as Egrifta, TH9507

FDA-approved GHRH analogue for HIV-associated lipodystrophy.

Medical status: Approved to reduce excess abdominal fat in HIV-associated lipodystrophy.

Also commonly used for (off-label)

Targeting visceral belly fat
Raising natural growth hormone
Body recomposition in mid-life

Off-label and research uses are what people report, not approved indications. Talk to a clinician before using any of them.

How it's taken (route)

Subcutaneous injection
a small shot into the fat just under the skin (belly, thigh, or love handle)

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Documented dose: 1–2 mg
Typical frequency: Once daily, 5 days per week
Cycle: 12 weeks on, 4 off
Half-life: ~26-38 minutes
Common vial sizes: 5 mg, 10 mg
Regulatory status: FDA-approved as Egrifta for a specific indication; other uses are off-label.

Dose on a U-100 syringe (1–2 mg)

Vial	BAC water	Draw
5 mg	1 mL	20–40 units
10 mg	2 mL	20–40 units
10 mg	2.5 mL	25–50 units

On a U-100 syringe, 100 units = 1 mL, and the syringe holds 100 units total. Most people keep a single subcutaneous injection under about 50 units — bigger volumes are usually mixed stronger (less water) or split into two shots. Only mixes that fit in one syringe are shown. Always double-check with the reconstitution calculator.

What it does

An FDA-approved growth-hormone-releasing peptide, best known for targeting visceral fat — the deep abdominal fat around the organs that is hardest to shift and most linked to health risk. What people look into it for: • Reducing deep belly fat specifically • Raising IGF-1 and supporting lean mass • Liver fat reduction • Cognitive benefits reported in some studies of older adults It is approved for HIV-associated lipodystrophy and studied elsewhere. Blood sugar should be watched, as it can drift upward.

Mechanism

Stabilised GHRH analogue stimulating endogenous GH secretion.

Storage — lyophilisedwhat's this?

Refrigerate 2-8C, protect from light.

Storage — reconstitutedwhat's this?

Store reconstituted tesamorelin at cool room temperature in a dark place (refrigeration encourages gelling), and finish the vial quickly — within about 2 weeks.

Reconstitution noteswhat's this?

Tesamorelin gels easily. Dissolve a 10 mg vial with about 0.5 ml of 0.6% acetic acid first, then add 2.5 ml bacteriostatic water — that gives 33 mcg per unit, so 1 mg is about 30 units and 2 mg about 60 units.

Stacks well with

Popular combinations reported in the community and research literature — not a recommendation. Adding peptides multiplies side-effect risk; check with a clinician.

Commonly reported side effects

Injection-site reactions
Joint pain
Peripheral oedema
Raised blood glucose

Contraindications noted

Active malignancy
Pregnancy
Pituitary disorders

Research notes

One of the few peptides here with approved human indications and published trial data.

Vendors carrying Tesamorelin

These research suppliers list this compound. Prices, vial sizes and testing vary — always check the current lot certificate before you buy.

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