SS-31
Also known as Elamipretide, MTP-131
Mitochondria-targeted peptide studied for mitochondrial disease.
Medical status: Investigational for rare mitochondrial and kidney disease.
Also commonly used for (off-label)
- Mitochondrial fatigue protocols
- Longevity and endurance research
Off-label and research uses are what people report, not approved indications. Talk to a clinician before using any of them.
How it's taken (route)
a small shot into the fat just under the skin (belly, thigh, or love handle)
New to peptides? Start with the beginner's guide.
- Documented dose
- 1–6 mg
- Typical frequency
- Once daily, 3–5 days per week (mornings)
- Cycle
- 12 weeks on, 4 off
- Half-life
- ~2 hours
- Common vial sizes
- 10 mg, 50 mg
- Regulatory status
- Investigational; not approved.
Dose on a U-100 syringe (1–6 mg)
| Vial | BAC water | Draw |
|---|---|---|
| 10 mg | 1 mL | 10–60 unitslarge volume |
| 10 mg | 1.5 mL | 15–90 unitslarge volume |
| 50 mg | 2.5 mL | 5.0–30 units |
| 50 mg | 3 mL | 6.0–36 units |
On a U-100 syringe, 100 units = 1 mL, and the syringe holds 100 units total. Most people keep a single subcutaneous injection under about 50 units — bigger volumes are usually mixed stronger (less water) or split into two shots. Only mixes that fit in one syringe are shown. Always double-check with the reconstitution calculator.
What it does
Also called elamipretide. It travels into the mitochondria and binds to cardiolipin, a fat that keeps the energy-producing machinery folded correctly. Think of it as tuning up the cell's power plants. What people look into it for: • Chronic fatigue and low energy tied to mitochondrial function • Heart and skeletal muscle performance • Recovery in older adults or after illness • Reducing oxidative stress and supporting healthy ageing It has been through real clinical trials for rare mitochondrial diseases, with mixed but promising results.
Mechanism
Binds cardiolipin on the inner mitochondrial membrane, improving electron transport efficiency.
Storage — lyophilisedwhat's this?
Refrigerate 2-8C, protect from light.
Storage — reconstitutedwhat's this?
Refrigerate 2-8C, use within ~28 days.
Reconstitution noteswhat's this?
Common mix: 10 mg vial + 2 ml bacteriostatic water = 50 mcg per unit, so 1 mg is 20 units, 3 mg is 60 units and the 6 mg ceiling is 100 units. A 50 mg vial + 3 ml gives 167 mcg per unit (3 mg ≈ 18 units).
Stacks well with
- MOTS-cTwo different mitochondrial mechanisms in one protocol.
- NAD+Energy production support alongside membrane protection.
- TesamorelinMitochondrial repair alongside a GH-driven fat-loss block.
Popular combinations reported in the community and research literature — not a recommendation. Adding peptides multiplies side-effect risk; check with a clinician.
Commonly reported side effects
- Injection-site reactions
- Headache
- Dizziness
Contraindications noted
- Pregnancy or breastfeeding
Research notes
In clinical trials as elamipretide for primary mitochondrial myopathy.
Vendors carrying SS-31
These research suppliers list this compound. Prices, vial sizes and testing vary — always check the current lot certificate before you buy.
- PeptideMaxxingpeptidemaxxing.com15% Off(opens in a new window)
- Peplair Researchpeplairresearch.shop(opens in a new window)
- Sports Technology Labssportstechnologylabs.com(opens in a new window)
- Value Research Labsvalueresearchlabs.com(opens in a new window)
Peptide Streak users get 15% off PeptideMaxxing with code PEPSTREAK.
Peptide Streak does not sell peptides and is not affiliated with these vendors. Some list metabolic compounds under coded product names.