longevitycognitive

NAD+

Also known as Nicotinamide adenine dinucleotide

Coenzyme used in energy metabolism and longevity protocols.

Medical status: Sold as a supplement or IV therapy rather than an approved drug.

Also commonly used for (off-label)

Energy and mental clarity
Longevity and cellular repair protocols
Recovery from burnout or jet lag

Off-label and research uses are what people report, not approved indications. Talk to a clinician before using any of them.

How it's taken

Subcutaneous injection
a small shot into the fat just under the skin (belly, thigh, or love handle)
Oral capsule or tablet
swallowed as a capsule or pill, usually on an empty stomach
Sublingual (under the tongue)
a drop or tablet held under the tongue until it dissolves

Availability varies by supplier — injectable is the most commonly researched form.

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Documented dose: 50–100 mg
Typical frequency: 2–7 times per week, in the morning
Cycle: 12 weeks on, 4 off
Half-life: Minutes (rapid clearance)
Common vial sizes: 500 mg, 1000 mg
Regulatory status: Sold as a supplement; injectable use unapproved.

Dose on a U-100 syringe (50–100 mg)

Vial	BAC water	Draw
500 mg	2 mL	20–40 units
500 mg	2.5 mL	25–50 units
1000 mg	3 mL	15–30 units
1000 mg	5 mL	25–50 units

On a U-100 syringe, 100 units = 1 mL, and the syringe holds 100 units total. Most people keep a single subcutaneous injection under about 50 units — bigger volumes are usually mixed stronger (less water) or split into two shots. Only mixes that fit in one syringe are shown. Always double-check with the reconstitution calculator.

What it does

Not a peptide but a coenzyme every cell uses to turn food into usable energy and to run DNA repair. Levels fall steadily with age, which is why it turns up in longevity protocols. What people look into it for: • More physical and mental energy, and less brain fog • Mitochondrial health and cellular repair • Recovery from heavy training, illness or jet lag • Healthy-ageing and cognitive support Injections and IV drips are used because oral NAD+ is poorly absorbed. Fast administration commonly causes a wave of flushing, nausea or chest tightness, so it is given slowly.

Mechanism

Substrate for sirtuins and PARPs; central to redox metabolism.

Storage — lyophilisedwhat's this?

Refrigerate 2-8C, protect from light.

Storage — reconstitutedwhat's this?

Refrigerate 2-8C, use within ~28 days.

Reconstitution noteswhat's this?

Common mix: 500 mg vial + 5 ml bacteriostatic water = 1 mg per unit, so 50 mg is 50 units and 100 mg fills the syringe. Inject slowly — NAD+ commonly causes flushing or a wave of nausea if pushed fast.

Stacks well with

Popular combinations reported in the community and research literature — not a recommendation. Adding peptides multiplies side-effect risk; check with a clinician.

Commonly reported side effects

Injection-site pain
Flushing
Nausea
Chest tightness if injected fast

Contraindications noted

Pregnancy or breastfeeding

Research notes

Subcutaneous dosing is uncomfortable; IV infusions are the studied route.

Vendors carrying NAD+

These research suppliers list this compound. Prices, vial sizes and testing vary — always check the current lot certificate before you buy.

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Peptide Streak does not sell peptides and is not affiliated with these vendors. Some list metabolic compounds under coded product names.