longevityfat loss

MOTS-c

Also known as Mitochondrial ORF of the 12S rRNA type-c

Mitochondrial-derived peptide studied for metabolic health.

Medical status: Not approved as a medicine.

Also commonly used for (off-label)

Exercise capacity and endurance
Insulin sensitivity and metabolic health

Off-label and research uses are what people report, not approved indications. Talk to a clinician before using any of them.

How it's taken (route)

Subcutaneous injection
a small shot into the fat just under the skin (belly, thigh, or love handle)

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Documented dose: 3–5 mg
Typical frequency: 5 mg every 5 days, or 3 mg every 3 days
Cycle: 8 weeks on, 4 off
Half-life: ~30 minutes
Common vial sizes: 10 mg, 20 mg
Regulatory status: Not approved for human use.

Dose on a U-100 syringe (3–5 mg)

Vial	BAC water	Draw
10 mg	1 mL	30–50 units
20 mg	1.5 mL	22–38 units
20 mg	2 mL	30–50 units

On a U-100 syringe, 100 units = 1 mL, and the syringe holds 100 units total. Most people keep a single subcutaneous injection under about 50 units — bigger volumes are usually mixed stronger (less water) or split into two shots. Only mixes that fit in one syringe are shown. Always double-check with the reconstitution calculator.

What it does

A peptide coded by mitochondrial DNA rather than the cell nucleus. It behaves like an exercise signal, telling muscle to burn glucose and fat more efficiently. What people look into it for: • Better insulin sensitivity and blood-sugar control • More endurance and exercise capacity — sometimes called an "exercise mimetic" • Fat loss and metabolic flexibility • Healthy-ageing protocols, since natural levels fall with age Most findings so far come from animal studies and small human observations.

Mechanism

Activates AMPK and folate-methionine cycle signalling, improving glucose utilisation.

Storage — lyophilisedwhat's this?

Refrigerate 2-8C, protect from light.

Storage — reconstitutedwhat's this?

Refrigerate 2-8C, use within ~28 days.

Reconstitution noteswhat's this?

Common mix: 10 mg vial + 1.5 ml bacteriostatic water = 67 mcg per unit, so 5 mg is about 75 units. A 20 mg vial + 3 ml gives the same draw. Dose first thing in the morning, fasted or before training.

Stacks well with

Popular combinations reported in the community and research literature — not a recommendation. Adding peptides multiplies side-effect risk; check with a clinician.

Commonly reported side effects

Fatigue
Flushing
Injection-site irritation

Contraindications noted

Pregnancy or breastfeeding

Research notes

Human data very limited; mostly mouse metabolic studies.

Vendors carrying MOTS-c

These research suppliers list this compound. Prices, vial sizes and testing vary — always check the current lot certificate before you buy.

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Peptide Streak does not sell peptides and is not affiliated with these vendors. Some list metabolic compounds under coded product names.