Tirzepatide
Also known as Mounjaro, Zepbound
Dual GIP and GLP-1 receptor agonist.
Medical status: Approved for type 2 diabetes, weight management, and obstructive sleep apnoea in obesity.
Also commonly used for (off-label)
- Aggressive weight loss
- Appetite and blood-sugar control
Off-label and research uses are what people report, not approved indications. Talk to a clinician before using any of them.
How it's taken (route)
a small shot into the fat just under the skin (belly, thigh, or love handle)
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- Documented dose
- 2500–15000 mcg
- Typical frequency
- Once weekly, same day each week — hold each dose at least 4 weeks before increasing
- Half-life
- ~5 days
- Common vial sizes
- 15 mg, 30 mg, 60 mg
- Regulatory status
- FDA-approved prescription medicine.
Dose on a U-100 syringe (2500–15000 mcg)
| Vial | BAC water | Draw |
|---|---|---|
| 15 mg | 1 mL | 17–100 unitslarge volume |
| 30 mg | 1 mL | 8.3–50 units |
| 60 mg | 1.5 mL | 6.3–38 units |
| 60 mg | 2 mL | 8.3–50 units |
On a U-100 syringe, 100 units = 1 mL, and the syringe holds 100 units total. Most people keep a single subcutaneous injection under about 50 units — bigger volumes are usually mixed stronger (less water) or split into two shots. Only mixes that fit in one syringe are shown. Always double-check with the reconstitution calculator.
What it does
A dual agonist that activates both GLP-1 and GIP receptors, the two main gut hormones that manage appetite and blood sugar. Hitting both tends to produce more weight loss than GLP-1 alone. Approved as Mounjaro and Zepbound. What people look into it for: • Large average weight loss in trials (often around 20% at higher doses) • Strong appetite reduction and fewer cravings • Excellent blood-sugar control in type 2 diabetes • Improvements in blood pressure, cholesterol and sleep apnoea Doses step up slowly to limit nausea and stomach upset. Protein intake and resistance training matter for keeping muscle.
Mechanism
Dual incretin agonism improving insulin secretion, satiety and gastric emptying.
Storage — lyophilisedwhat's this?
Refrigerate 2-8C, protect from light.
Storage — reconstitutedwhat's this?
Refrigerate 2-8C, use within ~28 days.
Reconstitution noteswhat's this?
Common mix: 30 mg vial + 1.5 ml bacteriostatic water = 200 mcg per unit, so 2.5 mg is about 12 units, 5 mg is 25 units and 15 mg is 75 units. A 60 mg vial + 2.5 ml gives a similar draw.
Stacks well with
- IpamorelinCommonly added to help preserve lean mass while losing weight fast.
- 5-Amino-1MQMetabolic support alongside appetite suppression.
- TesamorelinUsed when stubborn visceral fat is the main target.
Popular combinations reported in the community and research literature — not a recommendation. Adding peptides multiplies side-effect risk; check with a clinician.
Commonly reported side effects
- Nausea
- Diarrhoea
- Vomiting
- Decreased appetite
- Injection-site reactions
Contraindications noted
- Medullary thyroid carcinoma history
- MEN2
- Pregnancy
- Severe gastrointestinal disease
Research notes
Dose escalation over months is standard in the approved label.
Vendors carrying Tirzepatide
These research suppliers list this compound. Prices, vial sizes and testing vary — always check the current lot certificate before you buy.
- PeptideMaxxingpeptidemaxxing.com15% Off(opens in a new window)
- Modified Aminosmodifiedaminos.shop(opens in a new window)
- Penguin Peptidespenguinpeptides.com(opens in a new window)
- Peplair Researchpeplairresearch.shop(opens in a new window)
- Value Research Labsvalueresearchlabs.com(opens in a new window)
- Zeptix Labszeptixlabs.com15% Off(opens in a new window)
Peptide Streak users get 15% off PeptideMaxxing with code PEPSTREAK.
Peptide Streak users get 15% off Zeptix Labs with code PEPSTREAK.
Peptide Streak does not sell peptides and is not affiliated with these vendors. Some list metabolic compounds under coded product names.