Cagrilintide
Also known as AM833
Long-acting amylin analogue studied with semaglutide.
Medical status: Investigational — studied alongside semaglutide.
Also commonly used for (off-label)
- Extra appetite suppression on top of a GLP-1
- Slowing gastric emptying
Off-label and research uses are what people report, not approved indications. Talk to a clinician before using any of them.
How it's taken (route)
a small shot into the fat just under the skin (belly, thigh, or love handle)
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- Documented dose
- 200–2700 mcg
- Typical frequency
- Once weekly, same day each week
- Cycle
- 8 weeks on, 4 off
- Half-life
- ~7-8 days
- Common vial sizes
- 5 mg, 10 mg
- Regulatory status
- Investigational; not approved.
Dose on a U-100 syringe (200–2700 mcg)
| Vial | BAC water | Draw |
|---|---|---|
| 5 mg | 1 mL | 4.0–54 unitslarge volume |
| 5 mg | 1.5 mL | 6.0–81 unitslarge volume |
| 10 mg | 1 mL | 2.0–27 units |
| 10 mg | 1.5 mL | 3.0–41 units |
On a U-100 syringe, 100 units = 1 mL, and the syringe holds 100 units total. Most people keep a single subcutaneous injection under about 50 units — bigger volumes are usually mixed stronger (less water) or split into two shots. Only mixes that fit in one syringe are shown. Always double-check with the reconstitution calculator.
What it does
A long-acting copy of amylin, a hormone your pancreas releases with insulin to tell your brain you have eaten enough. It slows how fast the stomach empties, so meals feel filling for longer. What people look into it for: • Real reduction in hunger and food noise • Steady weight loss, especially when paired with a GLP-1 like semaglutide • Smaller portions feeling satisfying • Fewer cravings between meals It is still an investigational drug and is most studied as part of a combination.
Mechanism
Amylin receptor agonist promoting satiety and slowed gastric emptying.
Storage — lyophilisedwhat's this?
Refrigerate 2-8C, protect from light.
Storage — reconstitutedwhat's this?
Refrigerate 2-8C, use within ~28 days.
Reconstitution noteswhat's this?
Common mix: 10 mg vial + 2 ml bacteriostatic water = 50 mcg per unit. Typical titration: 200 mcg (4 units), 400 mcg (8), 750 mcg (15), 1.2 mg (24), 1.7 mg (34), 2.2 mg (44), 2.7 mg (54).
Stacks well with
- SemaglutideThe pairing it was designed around (CagriSema).
- TirzepatideUsed as a plateau-breaker alongside a dual agonist.
- RetatrutideAmylin signalling added to a triple agonist for appetite control.
Popular combinations reported in the community and research literature — not a recommendation. Adding peptides multiplies side-effect risk; check with a clinician.
Commonly reported side effects
- Nausea
- Vomiting
- Reduced appetite
- Injection-site reactions
Contraindications noted
- Pregnancy
- Severe gastrointestinal disease
Research notes
Investigational; trialled as CagriSema with semaglutide.
Vendors carrying Cagrilintide
These research suppliers list this compound. Prices, vial sizes and testing vary — always check the current lot certificate before you buy.
- PeptideMaxxingpeptidemaxxing.com15% Off(opens in a new window)
- Nexaphnexaph.com(opens in a new window)
- Modified Aminosmodifiedaminos.shop(opens in a new window)
- Penguin Peptidespenguinpeptides.com(opens in a new window)
- Peplair Researchpeplairresearch.shop(opens in a new window)
- Value Research Labsvalueresearchlabs.com(opens in a new window)
Peptide Streak users get 15% off PeptideMaxxing with code PEPSTREAK.
Peptide Streak does not sell peptides and is not affiliated with these vendors. Some list metabolic compounds under coded product names.