Retatrutide
Also known as LY3437943, Triple-G
Investigational triple GIP/GLP-1/glucagon receptor agonist.
Medical status: Investigational — not approved anywhere yet.
Also commonly used for (off-label)
- Research into next-generation weight loss
- Fat loss where GLP-1s have plateaued
Off-label and research uses are what people report, not approved indications. Talk to a clinician before using any of them.
How it's taken (route)
a small shot into the fat just under the skin (belly, thigh, or love handle)
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- Documented dose
- 2–12 mg
- Typical frequency
- Once weekly, same day each week — hold each dose at least 4 weeks before increasing
- Half-life
- ~6 days
- Common vial sizes
- 10 mg, 30 mg, 60 mg
- Regulatory status
- Investigational; not approved.
Dose on a U-100 syringe (2–12 mg)
| Vial | BAC water | Draw |
|---|---|---|
| 30 mg | 1 mL | 6.7–40 units |
| 60 mg | 2 mL | 6.7–40 units |
| 60 mg | 2.5 mL | 8.3–50 units |
On a U-100 syringe, 100 units = 1 mL, and the syringe holds 100 units total. Most people keep a single subcutaneous injection under about 50 units — bigger volumes are usually mixed stronger (less water) or split into two shots. Only mixes that fit in one syringe are shown. Always double-check with the reconstitution calculator.
What it does
An investigational "triple agonist" that hits three metabolic receptors at once — GLP-1, GIP and glucagon. The glucagon arm also raises energy burn, not just lowers appetite. What people look into it for: • The largest average weight loss reported in this drug class so far in trials • Strong appetite suppression and reduced food cravings • Blood-sugar control and reduced liver fat It is still in clinical trials and is not approved anywhere, so long-term safety is not established.
Mechanism
Triple agonism adds glucagon-receptor-driven energy expenditure to incretin effects.
Storage — lyophilisedwhat's this?
Refrigerate 2-8C, protect from light.
Storage — reconstitutedwhat's this?
Refrigerate 2-8C, use within ~28 days.
Reconstitution noteswhat's this?
Common mix: 30 mg vial + 2.5 ml bacteriostatic water = 120 mcg per unit, so 2 mg is about 16 units, 6 mg is 50 units and 12 mg is 100 units. Typical starting dose is 2 mg per week (4 mg if you have already stepped up on another GLP-1).
Stacks well with
- IpamorelinLean-mass support during rapid weight loss.
- 5-Amino-1MQPaired for fat metabolism through a separate pathway.
Popular combinations reported in the community and research literature — not a recommendation. Adding peptides multiplies side-effect risk; check with a clinician.
Commonly reported side effects
- Nausea
- Vomiting
- Increased heart rate
- Diarrhoea
Contraindications noted
- Pregnancy
- Thyroid C-cell tumour history
- Uncontrolled cardiovascular disease
Research notes
Still in clinical trials; no approved human product exists.
Vendors carrying Retatrutide
These research suppliers list this compound. Prices, vial sizes and testing vary — always check the current lot certificate before you buy.
- PeptideMaxxingpeptidemaxxing.com15% Off(opens in a new window)
- Modified Aminosmodifiedaminos.shop(opens in a new window)
- Penguin Peptidespenguinpeptides.com(opens in a new window)
- Peplair Researchpeplairresearch.shop(opens in a new window)
- Value Research Labsvalueresearchlabs.com(opens in a new window)
- Zeptix Labszeptixlabs.com15% Off(opens in a new window)
Peptide Streak users get 15% off PeptideMaxxing with code PEPSTREAK.
Peptide Streak users get 15% off Zeptix Labs with code PEPSTREAK.
Peptide Streak does not sell peptides and is not affiliated with these vendors. Some list metabolic compounds under coded product names.