Survodutide
Also known as BI 456906
A weekly GLP-1 plus glucagon dual agonist for significant weight loss.
How it's taken (route)
a small shot into the fat just under the skin (belly, thigh, or love handle)
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- Documented dose
- 1600–6400 mcg
- Typical frequency
- Once weekly, same day each week
- Cycle
- 26 weeks on, 8 off
- Half-life
- Suited to once-weekly dosing
- Common vial sizes
- 10 mg
- Regulatory status
- Investigational — not approved.
Dose on a U-100 syringe (1600–6400 mcg)
| Vial | BAC water | Draw |
|---|---|---|
| 10 mg | 1 mL | 16–64 unitslarge volume |
| 10 mg | 1.5 mL | 24–96 unitslarge volume |
On a U-100 syringe, 100 units = 1 mL, and the syringe holds 100 units total. Most people keep a single subcutaneous injection under about 50 units — bigger volumes are usually mixed stronger (less water) or split into two shots. Only mixes that fit in one syringe are shown. Always double-check with the reconstitution calculator.
What it does
Survodutide combines appetite suppression with a glucagon signal that raises energy expenditure and targets liver fat. Trial participants lost close to 19% of body weight. It is injected once a week and titrated slowly.
Mechanism
Dual agonist at the GLP-1 and glucagon receptors — GLP-1 cuts appetite and slows gastric emptying, glucagon increases energy expenditure and liver fat clearance.
Storage — lyophilisedwhat's this?
Refrigerate the sealed vial.
Storage — reconstitutedwhat's this?
Refrigerate and use within about 4-6 weeks.
Reconstitution noteswhat's this?
Mix a 10 mg vial with 1.5 mL (150 units) of bacteriostatic water. 12 units is 0.8 mg. Start at 24 units (1.6 mg) weekly and hold at least 4 weeks before increasing in 0.8 mg (12 unit) steps. 72 units (4.8 mg) is the trial dose; 96 units (6.4 mg) is the ceiling.
Stacks well with
- CagrilintideAmylin signalling added for stronger appetite control.
- IpamorelinHelps protect lean mass during rapid weight loss.
Popular combinations reported in the community and research literature — not a recommendation. Adding peptides multiplies side-effect risk; check with a clinician.
Commonly reported side effects
- Nausea
- Vomiting
- Constipation
- Fatigue
- Raised heart rate
Contraindications noted
- Medullary thyroid cancer history
- MEN2
- Pancreatitis
- Pregnancy
Research notes
Investigational. The glucagon arm makes titration slower and side effects more noticeable than a pure GLP-1.
Vendors carrying Survodutide
These research suppliers list this compound. Prices, vial sizes and testing vary — always check the current lot certificate before you buy.
Peptide Streak does not sell peptides and is not affiliated with these vendors. Some list metabolic compounds under coded product names.