Sermorelin
Also known as GHRH 1-29, Geref
GHRH 1-29 fragment used to stimulate natural GH release.
Medical status: Was approved for GH deficiency diagnosis; commonly compounded today.
Also commonly used for (off-label)
- Age-related GH decline
- Sleep, energy and recovery in anti-ageing clinics
Off-label and research uses are what people report, not approved indications. Talk to a clinician before using any of them.
How it's taken (route)
a small shot into the fat just under the skin (belly, thigh, or love handle)
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- Documented dose
- 200–600 mcg
- Typical frequency
- Once daily at bedtime, fasted
- Cycle
- 12 weeks on, 6 off
- Half-life
- ~10-20 minutes
- Common vial sizes
- 5 mg, 10 mg
- Regulatory status
- Previously approved; now compounded, regulatory status varies.
Dose on a U-100 syringe (200–600 mcg)
| Vial | BAC water | Draw |
|---|---|---|
| 5 mg | 2.5 mL | 10–30 units |
| 5 mg | 3 mL | 12–36 units |
| 10 mg | 2.5 mL | 5.0–15 units |
| 10 mg | 3 mL | 6.0–18 units |
On a U-100 syringe, 100 units = 1 mL, and the syringe holds 100 units total. Most people keep a single subcutaneous injection under about 50 units — bigger volumes are usually mixed stronger (less water) or split into two shots. Only mixes that fit in one syringe are shown. Always double-check with the reconstitution calculator.
What it does
The original growth-hormone-releasing peptide — a copy of the first 29 amino acids of the body's own GHRH. It asks the pituitary for growth hormone instead of supplying it from outside, so the body's own feedback controls stay in charge. What people look into it for: • Age-related decline in growth hormone in adults • Better sleep quality and recovery • Gradual improvements in body composition, skin and energy • A safer-feeling alternative to injected HGH Results build over months rather than weeks. It was previously used medically to diagnose growth hormone deficiency in children.
Mechanism
Binds pituitary GHRH receptors, preserving feedback-regulated GH pulses.
Storage — lyophilisedwhat's this?
Refrigerate 2-8C, protect from light.
Storage — reconstitutedwhat's this?
Refrigerate 2-8C, use within ~28 days.
Reconstitution noteswhat's this?
Common mix: 5 mg vial + 2.5 ml bacteriostatic water = 20 mcg per unit (200 mcg = 10 units). A 10 mg vial with the same 2.5 ml gives 40 mcg per unit (200 mcg = 5 units).
Stacks well with
- IpamorelinGentle GHRH plus a secretagogue — a milder alternative to the CJC stack.
- NAD+Common in general longevity and energy protocols.
Popular combinations reported in the community and research literature — not a recommendation. Adding peptides multiplies side-effect risk; check with a clinician.
Commonly reported side effects
- Injection-site redness
- Flushing
- Headache
- Dizziness
Contraindications noted
- Active malignancy
- Pregnancy or breastfeeding
Research notes
Withdrawn commercially in the US but widely compounded.
Vendors carrying Sermorelin
These research suppliers list this compound. Prices, vial sizes and testing vary — always check the current lot certificate before you buy.
- PeptideMaxxingpeptidemaxxing.com15% Off(opens in a new window)
- Nexaphnexaph.com(opens in a new window)
- Modified Aminosmodifiedaminos.shop(opens in a new window)
- Penguin Peptidespenguinpeptides.com(opens in a new window)
- Peplair Researchpeplairresearch.shop(opens in a new window)
- Biotech Peptidesbiotechpeptides.com(opens in a new window)
- Sports Technology Labssportstechnologylabs.com(opens in a new window)
- Core Peptidescorepeptides.com(opens in a new window)
- Value Research Labsvalueresearchlabs.com(opens in a new window)
Peptide Streak users get 15% off PeptideMaxxing with code PEPSTREAK.
Peptide Streak does not sell peptides and is not affiliated with these vendors. Some list metabolic compounds under coded product names.