Semax
Also known as ACTH 4-10 analogue
Russian nootropic peptide used intranasally.
Medical status: Approved in Russia for stroke and cognitive indications.
Also commonly used for (off-label)
- Focus, memory and mental stamina
- Brain-fog and burnout protocols
Off-label and research uses are what people report, not approved indications. Talk to a clinician before using any of them.
How it's taken
sprayed into the nose and absorbed through the nasal lining — no needles
a small shot into the fat just under the skin (belly, thigh, or love handle)
Availability varies by supplier — injectable is the most commonly researched form.
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- Documented dose
- 300–1000 mcg
- Typical frequency
- Once daily in the morning, 5–7 days a week
- Cycle
- 6 weeks on, 6 off
- Half-life
- ~30 minutes
- Common vial sizes
- 5 mg, 10 mg
- Regulatory status
- Approved in Russia only; unapproved elsewhere.
Dose on a U-100 syringe (300–1000 mcg)
| Vial | BAC water | Draw |
|---|---|---|
| 5 mg | 2 mL | 12–40 units |
| 5 mg | 2.5 mL | 15–50 units |
| 10 mg | 2.5 mL | 7.5–25 units |
| 10 mg | 3 mL | 9.0–30 units |
On a U-100 syringe, 100 units = 1 mL, and the syringe holds 100 units total. Most people keep a single subcutaneous injection under about 50 units — bigger volumes are usually mixed stronger (less water) or split into two shots. Only mixes that fit in one syringe are shown. Always double-check with the reconstitution calculator.
What it does
A modified fragment of ACTH with the hormonal effects stripped out, developed in Russia as a nootropic and stroke treatment. It raises BDNF and supports dopamine and serotonin activity. What people look into it for: • Sharper focus, memory and mental stamina • Protecting brain cells during and after stress or injury • Lifting low mood and motivation • Faster mental recovery after intense cognitive work Usually taken as a nasal spray. Widely used in Russia, but little Western clinical data.
Mechanism
ACTH fragment analogue increasing BDNF and modulating dopaminergic and serotonergic tone.
Storage — lyophilisedwhat's this?
Refrigerate 2-8C, protect from light.
Storage — reconstitutedwhat's this?
Refrigerate 2-8C, use within ~28 days.
Reconstitution noteswhat's this?
Common mix: 10 mg vial + 3 ml bacteriostatic water = 33 mcg per unit, so 300 mcg is about 10 units and 1 mg is about 30 units. Nasal drops are the other common route.
Stacks well with
- SelankFocus plus anxiety reduction, usually dosed together intranasally.
- DSIPAdded when sleep is the limiting factor on cognition.
Popular combinations reported in the community and research literature — not a recommendation. Adding peptides multiplies side-effect risk; check with a clinician.
Commonly reported side effects
- Nasal irritation
- Headache
- Irritability
Contraindications noted
- Pregnancy or breastfeeding
Research notes
Approved in Russia; little Western clinical data.
Vendors carrying Semax
These research suppliers list this compound. Prices, vial sizes and testing vary — always check the current lot certificate before you buy.
- PeptideMaxxingpeptidemaxxing.com15% Off(opens in a new window)
- Nexaphnexaph.com(opens in a new window)
- Modified Aminosmodifiedaminos.shop(opens in a new window)
- ReadyPepreadypep.com15% Off(opens in a new window)
- Penguin Peptidespenguinpeptides.com(opens in a new window)
- Peplair Researchpeplairresearch.shop(opens in a new window)
- Biotech Peptidesbiotechpeptides.com(opens in a new window)
- Sports Technology Labssportstechnologylabs.com(opens in a new window)
- Core Peptidescorepeptides.com(opens in a new window)
- Value Research Labsvalueresearchlabs.com(opens in a new window)
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Peptide Streak does not sell peptides and is not affiliated with these vendors. Some list metabolic compounds under coded product names.