Kisspeptin-10
Also known as KP-10, Metastin 45-54
Upstream regulator of the reproductive hormone axis.
Medical status: Not approved as a medicine; used in fertility research.
Also commonly used for (off-label)
- Testosterone and hormone-axis support
- Libido and fertility research
Off-label and research uses are what people report, not approved indications. Talk to a clinician before using any of them.
How it's taken (route)
a small shot into the fat just under the skin (belly, thigh, or love handle)
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- Documented dose
- 200–500 mcg
- Typical frequency
- Every other day, or about twice weekly
- Cycle
- 4 weeks on, 4 off
- Half-life
- ~4 minutes
- Common vial sizes
- 5 mg, 10 mg
- Regulatory status
- Not approved for human use.
Dose on a U-100 syringe (200–500 mcg)
| Vial | BAC water | Draw |
|---|---|---|
| 5 mg | 2.5 mL | 10–25 units |
| 5 mg | 3 mL | 12–30 units |
| 10 mg | 2.5 mL | 5.0–13 units |
| 10 mg | 3 mL | 6.0–15 units |
On a U-100 syringe, 100 units = 1 mL, and the syringe holds 100 units total. Most people keep a single subcutaneous injection under about 50 units — bigger volumes are usually mixed stronger (less water) or split into two shots. Only mixes that fit in one syringe are shown. Always double-check with the reconstitution calculator.
What it does
A signalling peptide that sits at the very top of the reproductive hormone chain. It tells the brain to release LH and FSH, which in turn tell the testes or ovaries to make testosterone or oestrogen. What people look into it for: • Supporting the body's own testosterone production rather than replacing it • Fertility testing and treatment research • Libido and sexual motivation — it also acts on emotional and reward areas of the brain • Restarting hormone signalling after suppression Effects are short-lived because it clears from the body quickly.
Mechanism
Stimulates GnRH neurons via KISS1R, increasing LH and FSH.
Storage — lyophilisedwhat's this?
Refrigerate 2-8C, protect from light.
Storage — reconstitutedwhat's this?
Refrigerate 2-8C, use within ~28 days.
Reconstitution noteswhat's this?
Common mix: 5 mg vial + 1.5 ml bacteriostatic water = 33 mcg per unit, so 200 mcg is 6 units and 500 mcg is 15 units. Dosing too often causes desensitisation, so twice a week is the usual sweet spot.
Stacks well with
- PT-141Hormone-axis support paired with direct arousal effects.
- TesamorelinHormone-axis support alongside GH and body-composition work.
Popular combinations reported in the community and research literature — not a recommendation. Adding peptides multiplies side-effect risk; check with a clinician.
Commonly reported side effects
- Flushing
- Headache
- Nausea
Contraindications noted
- Hormone-sensitive cancers
- Pregnancy
Research notes
Mostly used as a research probe of the HPG axis.
Vendors carrying Kisspeptin-10
These research suppliers list this compound. Prices, vial sizes and testing vary — always check the current lot certificate before you buy.
- Modified Aminosmodifiedaminos.shop(opens in a new window)
- ReadyPepreadypep.com15% Off(opens in a new window)
- Penguin Peptidespenguinpeptides.com(opens in a new window)
- Peplair Researchpeplairresearch.shop(opens in a new window)
- Biotech Peptidesbiotechpeptides.com(opens in a new window)
- Sports Technology Labssportstechnologylabs.com(opens in a new window)
- Core Peptidescorepeptides.com(opens in a new window)
- Value Research Labsvalueresearchlabs.com(opens in a new window)
PepStreak users get an exclusive 15% off ReadyPep.
Peptide Streak does not sell peptides and is not affiliated with these vendors. Some list metabolic compounds under coded product names.