FOX04-DRI
Also known as FOXO4-DRI, Proxofim
A senolytic peptide used to clear worn-out "zombie" cells.
How it's taken (route)
a small shot into the fat just under the skin (belly, thigh, or love handle)
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- Documented dose
- 250–500 mcg
- Typical frequency
- Once daily
- Cycle
- 12 weeks on, 6 off
- Half-life
- Short
- Common vial sizes
- 10 mg
- Regulatory status
- Research chemical — not approved for human use.
Dose on a U-100 syringe (250–500 mcg)
| Vial | BAC water | Draw |
|---|---|---|
| 10 mg | 2.5 mL | 6.3–13 units |
| 10 mg | 3 mL | 7.5–15 units |
On a U-100 syringe, 100 units = 1 mL, and the syringe holds 100 units total. Most people keep a single subcutaneous injection under about 50 units — bigger volumes are usually mixed stronger (less water) or split into two shots. Only mixes that fit in one syringe are shown. Always double-check with the reconstitution calculator.
What it does
FOX04-DRI is run in longevity protocols to help the body clear senescent cells — cells that have stopped dividing but keep pumping out inflammatory signals. People report better recovery, skin quality, and general vitality over a cycle, though the evidence is preclinical.
Mechanism
Disrupts the FOXO4-p53 interaction inside senescent cells, releasing p53 and allowing those cells to undergo apoptosis.
Storage — lyophilisedwhat's this?
Refrigerate the sealed vial.
Storage — reconstitutedwhat's this?
Refrigerate and use within about 4 weeks.
Reconstitution noteswhat's this?
Mix a 10 mg vial with 3 mL of bacteriostatic water (about 3.3 mg/mL). Weeks 1-4: 8 units (250 mcg). Weeks 5-8: 11 units (375 mcg). Weeks 9-16: 15 units (500 mcg).
Stacks well with
- EpitalonClearing senescent cells alongside telomere-focused longevity work.
- NAD+Cellular clean-up plus cellular energy.
Popular combinations reported in the community and research literature — not a recommendation. Adding peptides multiplies side-effect risk; check with a clinician.
Commonly reported side effects
- Fatigue during the first days
- Injection site reactions
- Temporary aches as cells clear
Contraindications noted
- Pregnancy
- Active infection or recent surgery
Research notes
Famous for mouse studies showing restored fur and kidney function. No human trials exist.
Vendors carrying FOX04-DRI
These research suppliers list this compound. Prices, vial sizes and testing vary — always check the current lot certificate before you buy.
- Penguin Peptidespenguinpeptides.com(opens in a new window)
- Core Peptidescorepeptides.com(opens in a new window)
Peptide Streak does not sell peptides and is not affiliated with these vendors. Some list metabolic compounds under coded product names.