KPV
Also known as Lysine-Proline-Valine, alpha-MSH 11-13
Anti-inflammatory tripeptide fragment of alpha-MSH.
Medical status: Not approved as a medicine.
Also commonly used for (off-label)
- Gut inflammation and IBD-type symptoms
- Skin flare-ups and irritation
Off-label and research uses are what people report, not approved indications. Talk to a clinician before using any of them.
How it's taken
a small shot into the fat just under the skin (belly, thigh, or love handle)
swallowed as a capsule or pill, usually on an empty stomach
Topical
a cream or serum applied to the skin over the target area
Availability varies by supplier — injectable is the most commonly researched form.
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- Documented dose
- 200–1000 mcg
- Typical frequency
- Once daily at a consistent time
- Cycle
- 8 weeks on, 4 off
- Half-life
- Short
- Common vial sizes
- 5 mg, 10 mg
- Regulatory status
- Not approved for human use.
Dose on a U-100 syringe (200–1000 mcg)
| Vial | BAC water | Draw |
|---|---|---|
| 5 mg | 2 mL | 8.0–40 units |
| 5 mg | 2.5 mL | 10–50 units |
| 10 mg | 2.5 mL | 5.0–25 units |
| 10 mg | 3 mL | 6.0–30 units |
On a U-100 syringe, 100 units = 1 mL, and the syringe holds 100 units total. Most people keep a single subcutaneous injection under about 50 units — bigger volumes are usually mixed stronger (less water) or split into two shots. Only mixes that fit in one syringe are shown. Always double-check with the reconstitution calculator.
What it does
A three-amino-acid fragment of the alpha-MSH hormone. Its whole job is turning down inflammation, and unlike steroids it does this without suppressing the immune system broadly. What people look into it for: • Gut inflammation — IBD, colitis and general gut irritation • Skin conditions such as eczema, acne, psoriasis and slow-healing wounds • General inflammation without immune suppression • Some antimicrobial activity It can be taken orally for gut issues, applied topically for skin, or injected.
Mechanism
Inhibits NF-kB signalling and pro-inflammatory cytokine release.
Storage — lyophilisedwhat's this?
Refrigerate 2-8C, protect from light.
Storage — reconstitutedwhat's this?
Refrigerate 2-8C, use within ~28 days.
Reconstitution noteswhat's this?
Common mix: 10 mg vial + 2.5 ml bacteriostatic water = 40 mcg per unit, so 200 mcg is 5 units and the usual 1 mg ceiling is 25 units. Start low and step up only as needed.
Stacks well with
- BPC-157Standard gut protocol pairing — anti-inflammatory plus mucosal repair.
- LL-37Combined when gut inflammation and bacterial overgrowth are both suspected.
Popular combinations reported in the community and research literature — not a recommendation. Adding peptides multiplies side-effect risk; check with a clinician.
Commonly reported side effects
- Injection-site irritation
- Mild fatigue
Contraindications noted
- Pregnancy or breastfeeding
Research notes
Preclinical colitis and dermatitis models dominate the evidence.
Vendors carrying KPV
These research suppliers list this compound. Prices, vial sizes and testing vary — always check the current lot certificate before you buy.
- PeptideMaxxingpeptidemaxxing.com15% Off(opens in a new window)
- Nexaphnexaph.com(opens in a new window)
- Modified Aminosmodifiedaminos.shop(opens in a new window)
- Penguin Peptidespenguinpeptides.com(opens in a new window)
- Peplair Researchpeplairresearch.shop(opens in a new window)
- Biotech Peptidesbiotechpeptides.com(opens in a new window)
- Sports Technology Labssportstechnologylabs.com(opens in a new window)
- Core Peptidescorepeptides.com(opens in a new window)
- Value Research Labsvalueresearchlabs.com(opens in a new window)
Peptide Streak users get 15% off PeptideMaxxing with code PEPSTREAK.
Peptide Streak does not sell peptides and is not affiliated with these vendors. Some list metabolic compounds under coded product names.