longevity

Glutathione

Also known as GSH, Reduced glutathione, L-Glutathione

Master antioxidant tripeptide used for detoxification, skin, and immune support research.

How it's taken (route)

Documented dose
200–600 mg
Typical frequency
2-3 times weekly
Cycle
8 weeks on
Half-life
~10-15 minutes in plasma; intracellular effects persist longer
Common vial sizes
600 mg, 1500 mg
Regulatory status
Research use only

Dose on a U-100 syringe (200–600 mg)

VialBAC waterDraw
600 mg1 mL33–100 unitslarge volume
1500 mg1 mL13–40 units

On a U-100 syringe, 100 units = 1 mL, and the syringe holds 100 units total. Most people keep a single subcutaneous injection under about 50 units — bigger volumes are usually mixed stronger (less water) or split into two shots. Only mixes that fit in one syringe are shown. Always double-check with the reconstitution calculator.

What it does

Glutathione is a tripeptide (glutamate-cysteine-glycine) and the body's primary intracellular antioxidant. Injectable glutathione is researched for oxidative stress reduction, liver support, immune modulation, and skin brightening.

Mechanism

Glutathione directly neutralizes free radicals and reactive oxygen species, recycles other antioxidants (vitamins C and E), and supports phase II liver detoxification via glutathione-S-transferase conjugation.

Storage — lyophilisedwhat's this?

Store lyophilized at 2-8C or -20C, tightly sealed; glutathione oxidizes readily when exposed to air.

Storage — reconstitutedwhat's this?

Refrigerate at 2-8C after reconstitution and use within 7-14 days; oxidation (yellowing) indicates degradation.

Reconstitution noteswhat's this?

Reconstitute with bacteriostatic water. Doses are large (200-600 mg), so expect bigger injection volumes; many researchers split doses across injection sites.

Commonly stacked with

  • NAD+
  • Vitamin C

Commonly reported side effects

  • Injection site discomfort
  • Transient flushing or lightheadedness
  • Zinc depletion with long-term high-dose use

Contraindications noted

  • Pregnancy or breastfeeding (insufficient data)
  • History of severe asthma (nebulized/injected forms reported to trigger bronchospasm)

Research notes

Oral glutathione has poor bioavailability, which is why injectable and liposomal forms are used in research. Long-term high dosing can lower zinc levels.

Vendors carrying Glutathione

These research suppliers list this compound. Prices, vial sizes and testing vary — always check the current lot certificate before you buy.

Peptide Streak users get 15% off PeptideMaxxing with code PEPSTREAK.

Peptide Streak does not sell peptides and is not affiliated with these vendors. Some list metabolic compounds under coded product names.

Track this properly

Work out syringe units with the calculator, or set up a full schedule in about a minute.

Reference information only, not medical advice. See our medical disclaimer.